Charlie Zink threw a 1-2-3 top of the 1st inning. The Sox then proceeded to pound out ten (10) runs, count 'em, yes TEN runs, 6 of them courtesy of Big Papi's 2 HR's in one inning! (When was the last time that happened?!)
I feel bad for Youk, though :-( He struck out twice in the inning :-(
I searched for 2 HR's in one inning and all I could find was this:
Most impressive home-run inning: Fernando Tatis, Cardinals, 1999
Hitting two home runs in one inning has been accomplished many times, but Tatis put a little twist to hit: both of his were grand slams, both hit off Chan Ho Park.
And found this at the same time:
Most memorable homer off someone wearing No. 99: Joe Carter off Mitch Williams, Game 6, 1993 World Series
Carter's one-out, three-run, bottom-of-the-ninth inning blast off Williams gave the Blue Jays an 8-6 victory to win the Series and gave us Carter's joyous romp around the bases.
UPDATE: From AP:
It was the fourth time in Red Sox history a player hit two homers in an inning. The last was Nomar Garciaparra in 2002.
The last time a player hit two home runs in the first inning was Aaron Boone of the Cincinnati Reds against the San Diego Padres on Aug. 9, 2002, according to the Elias Sports Bureau. Both were two-run shots.
Bret Boone and Mike Cameron were the last American Leaguers to do it, and they did it in the same game, according to Elias. On May 2, 2002, the pair hit back-to-back homers twice in the first inning for the Seattle Mariners against the Chicago White Sox.